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Dr. Paul D’Agostino
Über
Paul D'Agostino promovierte an der Western Sydney University über die vergleichende Genomik und Proteomik toxigener Cyanobakterien. Nach seiner Promotion arbeitete er im Labor von Prof. Brett Neilan an der University of New South Wales an der Biosynthese von cyanobakteriellen Toxinen. Im Jahr 2016 wechselte er in das Labor von Prof. Tobias Gulder an der Technischen Universität München, zunächst als TUM Foundation Fellow und dann als Marie Skłodowska-Curie Postdoctoral Fellow. Im Jahr 2019 setzte er seine Tätigkeit bei Prof. Gulder an der Technischen Universität Dresden fort und ist weiterhin Mitglied der Gruppe am HIPS.
Während seiner Postdoc-Zeit hat Paul an der Entwicklung der Direct Pathway Cloning (DiPaC) Strategie mitgearbeitet. Derzeit beschäftigt er sich mit der Genomsequenzierung und dem Genom-Mining von Cyanobakterien, um kryptische Stoffwechselwege zu identifizieren, gefolgt von DiPaC und heterologer Expression zur Entdeckung neuer Naturstoffe.
2025
MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, Bailey C, Barra L, Booth T, Bozhüyük K, …, Weber T, Medema M (2025)
Nucleic Acids Research 53 (D1): 678-690DOI: 10.1093/nar/gkae1115
The Maculalactone Biosynthetic Gene Cluster, a Cryptic Furanolide Pathway Revealed in Nodularia sp. NIES-3585
D’Agostino P, Castro R, Uka V, Saurav K, Milzarek T, Sester A, Schneider M, Gulder T (2025)
bioRxivDOI: 10.1101/2025.02.26.640319
2024
The underestimated fraction: diversity, challenges and novel insights into unicellular cyanobionts of lichens
Jung P, Briegel-Williams L, Büdel B, Schultz M, Nürnberg D, Grube M, D’Agostino P, Kaštovský J, Mareš J, Lorenz M, …, INCb, International Network for research on unicellular CyanoBionts from lichens (2024)
ISME Commun. 4 (1)DOI: 10.1093/ismeco/ycae069
Phylometagenomics of cycad coralloid roots reveals shared symbiotic signals
Bustos-Diaz E, Cruz-Perez A, Garfias-Gallegos D, D'Agostino P, Gehringer M, Cibrian-Jaramillo A, Barona-Gomez F (2024)
Microb. Genom. 10 (3)DOI: 10.1099/mgen.0.001207
S75 | CyanoMetDB | Comprehensive database of secondary metabolites from cyanobacteria - Version 03
Janssen E, Jones M, Pinto E, Dörr F, Torres M, Rios Jacinavicius F, Mazur-Marzec H, Szubert K, Konkel R, Tartaglione L, …, Reher R, Sieber S (2024)
BookDOI: 10.5281/zenodo.13854577
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas
Mo X, Pu Q, Lübken T, Yu G, Malay M, D'Agostino P, Gulder T (2024)
Cell Chem. Biol. 31 (12): 2128-2137DOI: 10.1016/j.chembiol.2024.09.002
Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications
Ilic-Tomic T, Kramar A, Kostic M, Vojnovic S, Milovanovic J, Petkovic M, D'Agostino P, Gulder T, Nikodinovic-Runic J (2024)
Front. Bioeng. Biotechnol. 12DOI: 10.3389/fbioe.2024.1466757
2023
S75 | CyanoMetDB | Comprehensive database of secondary metabolites from cyanobacteria - Version 02
Janssen E, Jones M, Pinto E, Dörr F, Torres M, Rios Jacinavicius F, Mazur-Marzec H, Szubert K, Konkel R, Tartaglione L, …, Dittmann E, Reher R (2023)
BookDOI: 10.5281/zenodo.7922070
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria
D'Agostino P (2023)
Nat. Prod. Rep. 40 (11): 1701-1717DOI: 10.1039/D3NP00011G
Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster
Ouyang X, D'Agostino P, Wahlsten M, Delbaje E, Jokela J, Permi P, Gaiani G, Poso A, Bartos P, Gulder T, Koistinen H, Fewer D (2023)
Org. Biomol. Chem. 21 (23): 4893-4908DOI: 10.1039/D3OB00385J
2022
Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production
Stevanovic M, D'Agostino P, Mojicevic M, Gulder T, Nikodinovic-Runic J, Vojnovic S (2022)
J. Appl. Microbiol. 133 (4): 2560-2568DOI: 10.1111/jam.15726
Discovery and Heterologous Expression of Microginins from Microcystis aeruginosa LEGE 91341
Eusébio N, Castelo-Branco R, Sousa D, Preto M, D'Agostino P, Gulder T, Leão P (2022)
ACS Synth. Biol. 11 (10): 3493-3503DOI: 10.1021/acssynbio.2c00389
Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly
D'Agostino P, Seel C, Ji X, Gulder T, Gulder T (2022)
Nat. Chem. Biol. 18 (6): 652-658DOI: 10.1038/s41589-022-01013-7
2021
Final Destination? Pinpointing Hyella disjuncta sp. nov. PCC 6712 (Cyanobacteria) Based on Taxonomic Aspects, Multicellularity, Nitrogen Fixation and Biosynthetic Gene Clusters
Jung P, D’Agostino P, Brust K, Büdel B, Lakatos M (2021)
Life 11 (9)DOI: 10.3390/life11090916
Symphyonema bifilamentata sp. nov., the right Fischerella ambigua 108b: Half a decade of research on taxonomy and bioactive compounds in new light
Jung P, D’Agostino P, Büdel B, Lakatos M (2021)
Microorganisms 9 (4)DOI: 10.3390/microorganisms9040745
Antarctic desert soil bacteria exhibit high novel natural product potential, evaluated through long-read genome sequencing and comparative genomics
Benaud N, Edwards R, Amos T, D'Agostino P, Gutiérrez-Chávez C, Montgomery K, Nicetic I, Ferrari B (2021)
Environ. Microbiol. 23 (7): 3646-3664DOI: 10.1111/1462-2920.15300
2020
Discovery of the Streptoketides by Direct Cloning and Rapid Heterologous Expression of a Cryptic PKS II Gene Cluster from Streptomyces sp. Tü 6314
Qian Z, Bruhn T, D'Agostino P, Herrmann A, Haslbeck M, Antal N, Fiedler H, Brack-Werner R, Gulder T (2020)
J. Org. Chem. 85 (2): 664-673DOI: 10.1021/acs.joc.9b02741
Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties
Mojicevic M, D'Agostino P, Pavic A, Vojnovic S, Senthamaraikannan R, Vasiljevic B, Gulder T, Nikodinovic-Runic J (2020)
MicrobiologyOpen 9 (3)DOI: 10.1002/mbo3.986
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity
Wylensek D, Hitch T, Riedel T, Afrizal A, Kumar N, Wortmann E, Liu T, Devendran S, Lesker T, Hernández S, …, Overmann J, Clavel T (2020)
Nat. Commun. 11 (1)DOI: 10.1038/s41467-020-19929-w
2019
Antifungal potential of bacterial rhizosphere isolates associated with three ethno-medicinal plants (poppy, chamomile, and nettle)
Mojicevic M, D'Agostino P, Nikodinovic-Runic J, Vasiljevic B, Gulder T, Vojnovic S (2019)
Int. Microbiol. 22 (3): 343-353DOI: 10.1007/s10123-019-00054-8
Bypassing Biocatalytic Substrate Limitations in Oxidative Dearomatization Reactions by Transient Substrate Mimicking
Milzarek T, Einsiedler M, Aldemir H, D'Agostino P, Evers J, Hertrampf G, Lamm K, Malay M, Matura A, Müller J, Gulder T (2019)
Org. Lett. 21 (12): 4520-4524DOI: 10.1021/acs.orglett.9b01398
Direct pathway cloning of the sodorifen biosynthetic gene cluster and recombinant generation of its product in E. coli
Duell E, D'Agostino P, Shapiro N, Woyke T, Fuchs T, Gulder T (2019)
Microb. Cell Fact. 18 (1)DOI: 10.1186/s12934-019-1080-6
2018
Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression
D'Agostino P, Gulder T (2018)
ACS Synth. Biol. 7 (7): 1702-1708DOI: 10.1021/acssynbio.8b00151
Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential
Greunke C, Duell E, D'Agostino P, Glöckle A, Lamm K, Gulder T (2018)
Metab. Eng. 47: 334-345DOI: 10.1016/j.ymben.2018.03.010