Dr Brigitta Loretz
About
Brigitta Loretz studied microbiology, did her diploma thesis at the Medical Chemistry and Biochemistry Department and her Ph.D. at the Pharmaceutical Technology Department, University of Innsbruck, Austria.
Her scientific interest is on carriers for intracellular delivery of biopharmaceutics, in particular, nucleotides, for the use in treatment/prevention of infectious diseases, and the development of new excipients, e.g. of new biodegradable polymers for this purpose. Her studies include delivery systems for antiinfectives, antigens or immune modulators as well as cell- or tissue-based models for the design/investigation of (nano)carrier-enabled delivery via non-invasive routes.
2024
Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery
Liu Y, Hamm T, Eichinger T, Kamm W, Wieland H, Loretz B, Hirsch A, Lee S, Lehr C (2024)
Int. J. Nanomedicine 19: 4429-4449DOI: 10.2147/IJN.S448578
A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response
Richter C, Latta L, Harig D, Carius P, Stucki J, Hobi N, Hugi A, Schumacher P, Krebs T, Gamrekeli A, …, Schneider-Daum N, Lehr C (2024)
Bioengineering & Transla MedDOI: 10.1002/btm2.10715
Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
Nnamani P, Nwagwu C, Diovu E, Abonyi O, Nesterkina M, Neu T, Richter C, Loretz B, Lehr C (2024)
Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114307
Biopolymeric and lipid-based nanotechnological strategies for the design and development of novel mosquito repellent systems: recent advances
Nwagwu C, Onugwu A, Echezona A, Uzondu S, Agbo C, Kenechukwu F, Ogbonna J, Ugorji L, Nwobi L, Nwobi O, …, Lehr C, Attama A (2024)
Nanoscale advances 6 (19): 4751-80DOI: 10.1039/d4na00474d
Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Nasr S, Paul P, Loretz B, Lehr C (2024)
Drug delivery and translational research 14 (12): 3339-3353DOI: 10.1007/s13346-024-01668-w
Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms
Bankar N, Latta L, Loretz B, Reda B, Dudek J, Hähl H, Hannig M, Lehr C (2024)
npj Biofilms and Microbiomes 10 (1)DOI: 10.1038/s41522-024-00569-7
A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics
Aliyazdi S, Frisch S, Neu T, Veldung B, Karande P, Schaefer U, Loretz B, Vogt T, Lehr C (2024)
ACS biomaterials science & engineering 10 (8): 4947-4957DOI: 10.1021/acsbiomaterials.4c00570
The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research
Mayoka G, Krug D, Loretz B, Bozhüyük K, Empting M, Hirsch A, Müller R (2024)
Trends in MicrobiologyDOI: 10.1016/j.tim.2024.07.007
Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides
Kamal M, Bassil J, Loretz B, Hirsch A, Lee S, Lehr C (2024)
Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114336
Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles
Andima M, Boese A, Paul P, Koch M, Loretz B, Lehr C (2024)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.4c00045
Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)
Floroiu A, Loretz B, Krämer J, Lehr C (2024)
Eur J Pharm Biopharm 197DOI: 10.1016/j.ejpb.2024.114206
2023
Overview of Inhaled Nanopharmaceuticals
Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho-Wodarz C, Lehr C (2023)
Journal of aerosol medicine and pulmonary drug delivery 36 (3): 144-151DOI: 10.1089/jamp.2023.29089.sb
Cell-Derived Vesicles for Antibiotic Delivery-Understanding the Challenges of a Biogenic Carrier System
Heinrich E, Hartwig O, Walt C, Kardani A, Koch M, Jahromi L, Hoppstädter J, Kiemer A, Loretz B, Lehr C, Fuhrmann G (2023)
Small (Weinheim an der Bergstrasse, Germany) 19 (25)DOI: 10.1002/smll.202207479
Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies
Arrua E, Hartwig O, Loretz B, Murgia X, Ho D, Bastiat G, Lehr C, Salomon C (2023)
Int. J. Pharm. 642DOI: 10.1016/j.ijpharm.2023.123120
Anti-Inflammatory and Antinociceptive Activity of Herbal Lipospheres of Pentaclethra macrophylla (Fabaceae) Stem Bark Extract
Nnamani P, Diovu E, Peter I, Onwuka A, Ogbuanwu C, Abonyi O, Loretz B, Lehr C (2023)
Processes 11 (9)DOI: 10.3390/pr11092557
Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development
Bali A, Kamal M, Mulla G, Loretz B, Lehr C (2023)
Advanced Functional Materials 33 (45)DOI: 10.1002/adfm.202304370
3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models
Aliyazdi S, Frisch S, Hidalgo A, Frank N, Krug D, Müller R, Schaefer U, Vogt T, Loretz B, Lehr C (2023)
Biofabrication 15 (3)DOI: 10.1088/1758-5090/acd95e
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)
ACS Cent. Sci. 9 (12): 2205-2215DOI: 10.1021/acscentsci.3c01102
Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor
Berwanger A, Stein S, Kany A, Gartner M, Loretz B, Lehr C, Hirsch A, Schulz T, Empting M (2023)
Journal of medicinal chemistry 66 (15): 10782-10790DOI: 10.1021/acs.jmedchem.3c00990
pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA
Liu Y, Ashmawy S, Latta L, Weiss A, Kiefer A, Nasr S, Loretz B, Hirsch A, Lee S, Lehr C (2023)
Biomacromolecules 24 (8): 3742-3754DOI: 10.1021/acs.biomac.3c00424
2022
Improving the oral delivery of benznidazole nanoparticles by optimizing the formulation parameters through a design of experiment and optimization strategy
Arrua E, Hartwig O, Loretz B, Goicoechea H, Murgia X, Lehr C, Salomon C (2022)
Colloids and surfaces. B, Biointerfaces 217DOI: 10.1016/j.colsurfb.2022.112678
Lipid-Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media
Kliesch L, Delandre S, Gabelmann A, Koch M, Schulze K, Guzmán C, Loretz B, Lehr C (2022)
Pharmaceutics 14 (12)DOI: 10.3390/pharmaceutics14122675
Intracellular Dynamics of Extracellular Vesicles by Segmented Trajectory Analysis
Rautaniemi K, John T, Richter M, Huck B, Zini J, Loretz B, Lehr C, Vuorimaa-Laukkanen E, Lisitsyna E, Laaksonen T (2022)
Analytical chemistry 94 (51): 17770-17778DOI: 10.1021/acs.analchem.2c02928
Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape
Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, …, Hirsch A, Lehr C (2022)
Journal of controlled release : official journal of the Controlled Release Society 353: 915-929DOI: 10.1016/j.jconrel.2022.12.018
Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1
Hartwig O, Loretz B, Nougarede A, Jary D, Sulpice E, Gidrol X, Navarro F, Lehr C (2022)
J Control Release 345: 646-660DOI: 10.1016/j.jconrel.2022.03.037
Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery
Huck B, Thiyagarajan D, Bali A, Boese A, Besecke K, Hozsa C, Gieseler R, Furch M, Carvalho-Wodarz C, Waldow F, …, Loretz B, Lehr C (2022)
Advanced healthcare materials 11 (11)DOI: 10.1002/adhm.202102117
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties
Huck B, Murgia X, Frisch S, Hittinger M, Hidalgo A, Loretz B, Lehr C (2022)
Advanced Drug Delivery Reviews 183DOI: 10.1016/j.addr.2022.114141
2021
Towards the sustainable discovery and development of new antibiotics
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)
Nature reviews. Chemistry 5 (10): 726-749DOI: 10.1038/s41570-021-00313-1
Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers
Arrua E, Hartwig O, Ho D, Loretz B, Murgia X, Salomon C, Lehr C (2021)
Pharmaceutical research 38 (6): 1081-1092DOI: 10.1007/s11095-021-03056-2
Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems
Nasr S, Lee S, Thiyagarajan D, Boese A, Loretz B, Lehr C (2021)
Pharmaceutics 13 (11)DOI: 10.3390/pharmaceutics13111924
A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms
Frisch S, Boese A, Huck B, Horstmann J, Ho D, Schwarzkopf K, Murgia X, Loretz B, Souza Carvalho-Wodarz C, Lehr C (2021)
The Journal of antimicrobial chemotherapy 76 (6): 1472-1479DOI: 10.1093/jac/dkab068
Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study
Hering S, Schäuble N, Buck T, Loretz B, Rillmann T, Stieneker F, Lehr C (2021)
Processes 9 (1)DOI: 10.3390/pr9010067
Drug delivery for fighting infectious diseases: a global perspective
Loretz B, Oh Y, Hudson S, Gu Z, Lehr C (2021)
Drug delivery and translational research 11 (4): 1316-1322DOI: 10.1007/s13346-021-01009-1
Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines
Ladaycia A, Loretz B, Passirani C, Lehr C, Lepeltier E (2021)
Advanced Drug Delivery Reviews 170: 44-70DOI: 10.1016/j.addr.2020.12.015
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12)DOI: 10.1002/advs.202004369
Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals
Thiyagarajan D, Huck B, Nothdurft B, Koch M, Rudolph D, Rutschmann M, Feldmann C, Hozsa C, Furch M, Besecke K, …, Loretz B, Lehr C (2021)
Drug delivery and translational research 11 (4): 1766-1778DOI: 10.1007/s13346-021-01011-7
2020
Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform
Ho D, Christmann R, Murgia X, Rossi C, Frisch S, Koch M, Schaefer U, Loretz B, Desmaele D, Couvreur P, Lehr C (2020)
Frontiers in chemistry 8DOI: 10.3389/fchem.2020.584242
Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases
Christmann R, Ho D, Wilzopolski J, Lee S, Koch M, Loretz B, Vogt T, Bäumer W, Schaefer U, Lehr C (2020)
Pharmaceutics 12 (12)DOI: 10.3390/pharmaceutics12121131
Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata
Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)
The Journal of investigative dermatology 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028
pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)
Mater. Chem. Front. 4 (3): 905-909DOI: 10.1039/C9QM00651F
Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms
Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)
Pharmaceutics 12 (8)DOI: 10.3390/pharmaceutics12080691
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407
2019
Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus
Huck B, Hartwig O, Biehl A, Schwarzkopf K, Wagner C, Loretz B, Murgia X, Lehr C (2019)
Biomacromolecules 20 (9): 3504-3512DOI: 10.1021/acs.biomac.9b00780
Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections
Ho D, Nichols B, Edgar K, Murgia X, Loretz B, Lehr C (2019)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2019.09.002
Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica
Menina S, Eisenbeis J, Kamal M, Koch M, Bischoff M, Gordon S, Loretz B, Lehr C (2019)
Advanced healthcare materials 8 (17)DOI: 10.1002/adhm.201900564
Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells
Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr C (2019)
Nanomedicine : nanotechnology, biology, and medicine 21DOI: 10.1016/j.nano.2019.102073
2018
Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles
Yasar H, Biehl A, Rossi C, Koch M, Murgia X, Loretz B, Lehr C (2018)
Journal of nanobiotechnology 16 (1)DOI: 10.1186/s12951-018-0401-y
Can lifecycle management safeguard innovation in the pharmaceutical industry?
Hering S, Loretz B, Friedli T, Lehr C, Stieneker F (2018)
Drug Discovery TodayDOI: 10.1016/j.drudis.2018.10.008
The role of mucus on drug transport and its potential to affect therapeutic outcomes
Murgia X, Loretz B, Hartwig O, Hittinger M, Lehr C (2018)
Advanced Drug Delivery Reviews 124: 82-97DOI: 10.1016/j.addr.2017.10.009
Oral delivery of macromolecular drugs
Savla R, Hartwig O, Lim Chin W, Loretz B, Lehr C (2018)
Pharm. Technol. Eur. 30 (7): 22-26
Farnesylated Glycol Chitosan as a Platform for Drug Delivery
Ho D, Frisch S, Biehl A, Terriac E, Rossi C, Schwarzkopf K, Lautenschläger F, Loretz B, Murgia X, Lehr C (2018)
Biomacromolecules 19 (8): 3489-3501DOI: 10.1021/acs.biomac.8b00795
Chemically modified h CFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis
Haque, A. K. M. Ashiqul, Dewerth A, Antony J, Riethmüller J, Schweizer G, Weinmann P, Latifi N, Yasar H, Pedemonte N, …, Handgretinger R, Kormann M (2018)
Scientific Reports 8 (1)DOI: 10.1038/s41598-018-34960-0
Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin
Ho D, Costa A, Rossi C, Souza Carvalho-Wodarz C, Loretz B, Lehr C (2018)
Molecular pharmaceutics 15 (3): 1081-1096DOI: 10.1021/acs.molpharmaceut.7b00967
A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes
Serr I, Scherm M, Zahm A, Schug J, Flynn V, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, …, Ziegler A, Daniel C (2018)
Science translational medicine 10 (422)DOI: 10.1126/scitranslmed.aag1782
Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines
Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2018)
ALTEX 35 (2): 211-222DOI: 10.14573/altex.1607191
Starch-Chitosan Polyplexes
Yasar H, Ho D, Rossi C, Herrmann J, Gordon S, Loretz B, Lehr C (2018)
Polymers 10 (3)DOI: 10.3390/polym10030252
Postmenopausaler Lichen planopilaris alias fibrosierende frontotemporale Alopezie Kossard
Vogt T, Thomas C, Reichrath J, Schilling L, Mawlood D, Christmann R, Loretz B, Schäfer U, Lehr C, Müller C (2018)
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 69 (2): 134-142DOI: 10.1007/s00105-017-4118-x
2017
Permanent gene correction by means of nucleotide-modified messenger RNA
Kormann M, Lehr C, Loretz B, Malaeksefat E (2017)
Patent (DE/08.10.13/ DEA102013111099)
Modelling the bronchial barrier in pulmonary drug delivery
Murgia X, Yasar H, Carvalho-Wodarz C, Loretz B, Gordon S, Schwarzkopf K, Schaefer U, Lehr C (2017)
European Journal of Pharmaceutics and Biopharmaceutics 118: 79-88DOI: 10.1016/j.ejpb.2017.03.020
Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency
Thiele C, Loretz B, Lehr C (2017)
Drug delivery and translational research 7 (2): 252-258DOI: 10.1007/s13346-016-0333-8
2016
Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities
Mostaghaci B, Loretz B, Lehr C (2016)
Current Pharmaceutical Design 22 (11): 1529-33
Preparation of nanosized coacervates of positive and negative starch derivatives intended for pulmonary delivery of proteins
Barthold S, Kletting S, Taffner J, De Souza Carvalho-Wodarz C, Lepeltier E, Loretz B, Lehr C (2016)
Journal of Materials Chemistry B 4 (13): 2377-2386DOI: 10.1039/c6tb00178e
Self-Assembly and Shape Control of Hybrid Nanocarriers Based on Calcium Carbonate and Carbon Nanodots
Lauth V, Loretz B, Lehr C, Maas M, Rezwan K (2016)
Chemistry of Materials 28 (11): 3796-3803DOI: 10.1021/acs.chemmater.6b00769
Design of Polyamine-Grafted Starches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity
Kanber E, Yamada H, Loretz B, Lepeltier E, Lehr C (2016)
Bioconjugate chemistryDOI: 10.1021/acs.bioconjchem.6b00396
Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part II: evaluation of IL-10-loaded microparticles for the treatment of lung inflammation
Hittinger M, Mell N, Huwer H, Loretz B, Schneider-Daum N, Lehr C (2016)
Alternatives to laboratory animals : ATLA 44 (4): 349-360
miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity
Serr I, Furst R, Ott V, Scherm M, Nikolaev A, Gokmen F, Kalin S, Zillmer S, Bunk M, Weigmann B, …, Ziegler A, Daniel C (2016)
Proceedings of the National Academy of Sciences of the United States of America 113 (43): 6659-DOI: 10.1073/pnas.1606646113
2015
Overview of Inhaled Nanopharmaceuticals
Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho Wodarz C, Lehr C (2015)
Book
P-glycoprotein interactions of novel psychoactive substances - stimulation of ATP consumption and transport across Caco-2 monolayers
Meyer M, Wagmann L, Schneider-Daum N, Loretz B, Souza Carvalho C, Lehr C, Maurer H (2015)
Biochemical pharmacology 94 (3): 220-6DOI: 10.1016/j.bcp.2015.01.008
Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane
Dandekar P, Jain R, Keil M, Loretz B, Koch M, Wenz G, Lehr C (2015)
Journal of Materials Chemistry B 3 (13): 2590-2598DOI: 10.1039/c4tb01821d
Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study
Mostaghaci B, Susewind J, Kickelbick G, Lehr C, Loretz B (2015)
ACS applied materials & interfaces 7 (9): 5124-33DOI: 10.1021/am507193a
In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency
Mahiny A, Dewerth A, Mays L, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch D, Reautschnig P, …, Lehr C, Kormann M (2015)
Nature biotechnology 33 (6): 584-6DOI: 10.1038/nbt.3241
Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin
Nafee N, Hirosue M, Loretz B, Wenz G, Lehr C (2015)
Colloids and surfaces. B, Biointerfaces 129: 30-8DOI: 10.1016/j.colsurfb.2015.03.014
Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages
Jain R, Dandekar P, Loretz B, Koch M, Lehr C (2015)
MedChemComm 6 (4): 691-701DOI: 10.1039/c4md00490f
Squalenoylation of Chitosan: A Platform for Drug Delivery?
Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C (2015)
Biomacromolecules 16 (9): 2930-9DOI: 10.1021/acs.biomac.5b00840
2014
Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform
Yamada H, Loretz B, Lehr C (2014)
Biomacromolecules 15 (5): 1753-61DOI: 10.1021/bm500128k
Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery
Blaudszun A, Lian Q, Schnabel M, Loretz B, Steinfeld U, Lee H, Wenz G, Lehr C, Schneider M, Philippi A (2014)
International journal of pharmaceutics 474 (1-2): 70-9DOI: 10.1016/j.ijpharm.2014.07.048
2013
Crossing biological barriers for advanced drug delivery
Schneider M, Windbergs M, Daum N, Loretz B, Collnot E, Hansen S, Schaefer U, Lehr C (2013)
European Journal of Pharmaceutics and Biopharmaceutics 84 (2): 239-241DOI: 10.1016/j.ejpb.2013.03.009
One-step synthesis of nanosized and stable amino-functionalized calcium phosphate particles for DNA transfection
Mostaghaci B, Loretz B, Haberkorn R, Kickelbick G, Lehr C (2013)
Chemistry of Materials 25 (18): 3667-3674DOI: 10.1021/cm401886u
2012
Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes
Dandekar P, Jain R, Keil M, Loretz B, Muijs L, Schneider M, Auerbach D, Jung G, Lehr C, Wenz G (2012)
Journal of controlled release : official journal of the Controlled Release Society 164 (3): 387-93DOI: 10.1016/j.jconrel.2012.06.040
A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel
Dandekar P, Jain R, Stauner T, Loretz B, Koch M, Wenz G, Lehr C (2012)
Macromolecular Bioscience 12 (2): 184-94DOI: 10.1002/mabi.201100244
Pulmonary delivery and tissue distribution of aerosolized antisense 2'-O-Methyl RNA containing nanoplexes in the isolated perfused and ventilated rat lung
Dong M, Murdter T, Philippi C, Loretz B, Schaefer U, Lehr C, Schwab M, Ammon-Treiber S (2012)
European Journal of Pharmaceutics and Biopharmaceutics 81 (3): 478-85DOI: 10.1016/j.ejpb.2012.04.022
2011
Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA
Dong M, Philippi C, Loretz B, Nafee N, Schaefer U, Friedel G, Ammon-Treiber S, Griese E, Lehr C, Klotz U, Murdter T (2011)
International journal of pharmaceutics 419 (1-2): 33-42DOI: 10.1016/j.ijpharm.2011.07.009
Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol
Jain R, Dandekar P, Loretz B, Melero A, Stauner T, Wenz G, Koch M, Lehr C (2011)
International journal of pharmaceutics 420 (1): 147-55DOI: 10.1016/j.ijpharm.2011.08.030
2010
Telomerase as an emerging target to fight cancer - Opportunities and challenges for nanomedicine
Philippi C, Loretz B, Schaefer U, Lehr C (2010)
Journal of Controlled Release 146 (2): 228-240DOI: 10.1016/j.jconrel.2010.03.025
Nanoparticles made from novel starch derivatives for transdermal drug delivery
Santander-Ortega M, Stauner T, Loretz B, Ortega-Vinuesa J, Bastos-Gonzalez D, Wenz G, Schaefer U, Lehr C (2010)
Journal of controlled release : official journal of the Controlled Release Society 141 (1): 85-92DOI: 10.1016/j.jconrel.2009.08.012