Dr Fabian Kern
About
Dr. Fabian Kern studied Bioinformatics with an emphasis on Computer Science and methodology as an undergraduate (Bachelor of Science) at Saarland University, and then successfully finished his Master of Science with distinction (Honor’s degree) at the Center for Bioinformatics located on campus. Subsequently, he started as a PhD student in the Medical Faculty of Saarland University working in the group Clinical Bioinformatics headed by Prof. Dr. Andreas Keller. During the time as a doctoral student, he contributed to more than 30 peer-reviewed research articles and completed numerous scientific collaborations with both national and international institutions. In late 2021 he finished his PhD (Dr. rer. nat.) in Natural Sciences and Medicine with distinction (summa cum laude) and a dissertation entitled “Algorithms and Applications for non-coding RNAs in Aging”. Since spring 2022 he heads a Junior Research Group at the HIPS working on new bioinformatics approaches and methods to aid infection research and anti-infective development using spatially and temporally resolved RNA-sequencing, especially at the single-cell level.
2024
Mibianto: ultra-efficient online microbiome analysis through k-mer based metagenomics
Hirsch P, Molano L, Engel A, Zentgraf J, Rahmann S, Hannig M, Müller R, Kern F, Keller A, Schmartz G (2024)
Nucleic Acids ResDOI: 10.1093/nar/gkae364
SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination
Iram T, Garcia M, Amand J, Kaur A, Atkins M, Iyer M, Lam M, Ambiel N, Jorgens D, Keller A, …, Kern F, Zuchero J (2024)
Proc. Natl. Acad. Sci. U.S.A. 121 (12)DOI: 10.1073/pnas.2307250121
ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution
Flotho M, Amand J, Hirsch P, Grandke F, Wyss-Coray T, Keller A, Kern F (2024)
Nucleic Acids Res 52 (D1): 1089-DOI: 10.1093/nar/gkad990
2023
Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation
Herppich S, Hoenicke L, Kern F, Kruse F, Smout J, Greweling-Pils M, Geffers R, Burton O, Liston A, Keller A, Floess S, Huehn J (2023)
European journal of immunologyDOI: 10.1002/eji.202250270
Atlas of the aging mouse brain reveals white matter as vulnerable foci
Hahn O, Foltz A, Atkins M, Kedir B, Moran-Losada P, Guldner I, Munson C, Kern F, Pálovics R, Lu N, …, Keller A, Wyss-Coray T (2023)
CellDOI: 10.1016/j.cell.2023.07.027
Ageing-associated small RNA cargo of extracellular vesicles
Kern F, Kuhn T, Ludwig N, Simon M, Gröger L, Fabis N, Aparicio-Puerta E, Salhab A, Fehlmann T, Hahn O, …, Laschke M, Keller A (2023)
RNA biology 20 (1): 482-494DOI: 10.1080/15476286.2023.2234713
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
Wagner V, Kern F, Hahn O, Schaum N, Ludwig N, Fehlmann T, Engel A, Henn D, Rishik S, Isakova A, …, Wyss-Coray T, Keller A (2023)
Nat BiotechnolDOI: 10.1038/s41587-023-01751-6
miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations
Aparicio-Puerta E, Hirsch P, Schmartz G, Kern F, Fehlmann T, Keller A (2023)
Nucleic Acids ResDOI: 10.1093/nar/gkad392
2022
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Iram T, Kern F, Kaur A, Myneni S, Morningstar A, Shin H, Garcia M, Yerra L, Palovics R, Yang A, …, Zuchero J, Wyss-Coray T (2022)
Nature 605 (7910): 509-515DOI: 10.1038/s41586-022-04722-0
BusyBee Web: towards comprehensive and differential composition-based metagenomic binning
Schmartz G, Hirsch P, Amand J, Dastbaz J, Fehlmann T, Kern F, Müller R, Keller A (2022)
Nucleic Acids ResDOI: 10.1093/nar/gkac298
PLSDB: advancing a comprehensive database of bacterial plasmids
Schmartz G, Hartung A, Hirsch P, Kern F, Fehlmann T, Müller R, Keller A (2022)
Nucleic Acids Res 50 (D1): 273-DOI: 10.1093/nar/gkab1111
2021
miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale
Fehlmann T, Kern F, Laham O, Backes C, Solomon J, Hirsch P, Volz C, Müller R, Keller A (2021)
Nucleic Acids ResDOI: 10.1093/nar/gkab268