Dr Paul D’Agostino
About
Paul D’Agostino obtained his PhD from the Western Sydney University which focused on comparative genomics and proteomics of toxigenic cyanobacteria. After his PhD, he worked in the laboratory of Prof. Brett Neilan at the University of New South Wales on the biosynthesis of cyanobacterial toxins. In 2016, he moved to the laboratory of Prof. Tobias Gulder at the Technische Universität München first as a TUM Foundation Fellow and then as a Marie Skłodowska-Curie Postdoctoral Fellow. In 2019, he continued his position with Prof. Gulder at the Technical University of Dresden and is still a member of the group at HIPS.
During his postdoctoral positions, Paul helped to develop the Direct Pathway Cloning (DiPaC) strategy. Currently he is involved in genome sequencing and genome mining of cyanobacteria to identify cryptic pathways of interest followed by DiPaC and heterologous expression to discover of novel natural products.
2025
MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, Bailey C, Barra L, Booth T, Bozhüyük K, …, Weber T, Medema M (2025)
Nucleic Acids Research 53 (D1): 678-690DOI: 10.1093/nar/gkae1115
The Maculalactone Biosynthetic Gene Cluster, a Cryptic Furanolide Pathway Revealed in Nodularia sp. NIES-3585
D’Agostino P, Castro R, Uka V, Saurav K, Milzarek T, Sester A, Schneider M, Gulder T (2025)
bioRxivDOI: 10.1101/2025.02.26.640319
2024
S75 | CyanoMetDB | Comprehensive database of secondary metabolites from cyanobacteria - Version 03
Janssen E, Jones M, Pinto E, Dörr F, Torres M, Rios Jacinavicius F, Mazur-Marzec H, Szubert K, Konkel R, Tartaglione L, …, Reher R, Sieber S (2024)
BookDOI: 10.5281/zenodo.13854577
The underestimated fraction: diversity, challenges and novel insights into unicellular cyanobionts of lichens
Jung P, Briegel-Williams L, Büdel B, Schultz M, Nürnberg D, Grube M, D’Agostino P, Kaštovský J, Mareš J, Lorenz M, …, INCb, International Network for research on unicellular CyanoBionts from lichens (2024)
ISME Commun. 4 (1)DOI: 10.1093/ismeco/ycae069
Phylometagenomics of cycad coralloid roots reveals shared symbiotic signals
Bustos-Diaz E, Cruz-Perez A, Garfias-Gallegos D, D'Agostino P, Gehringer M, Cibrian-Jaramillo A, Barona-Gomez F (2024)
Microb. Genom. 10 (3)DOI: 10.1099/mgen.0.001207
Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications
Ilic-Tomic T, Kramar A, Kostic M, Vojnovic S, Milovanovic J, Petkovic M, D'Agostino P, Gulder T, Nikodinovic-Runic J (2024)
Front. Bioeng. Biotechnol. 12DOI: 10.3389/fbioe.2024.1466757
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas
Mo X, Pu Q, Lübken T, Yu G, Malay M, D'Agostino P, Gulder T (2024)
Cell Chem. Biol. 31 (12): 2128-2137DOI: 10.1016/j.chembiol.2024.09.002
2023
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria
D'Agostino P (2023)
Nat. Prod. Rep. 40 (11): 1701-1717DOI: 10.1039/D3NP00011G
S75 | CyanoMetDB | Comprehensive database of secondary metabolites from cyanobacteria - Version 02
Janssen E, Jones M, Pinto E, Dörr F, Torres M, Rios Jacinavicius F, Mazur-Marzec H, Szubert K, Konkel R, Tartaglione L, …, Dittmann E, Reher R (2023)
BookDOI: 10.5281/zenodo.7922070
Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster
Ouyang X, D'Agostino P, Wahlsten M, Delbaje E, Jokela J, Permi P, Gaiani G, Poso A, Bartos P, Gulder T, Koistinen H, Fewer D (2023)
Org. Biomol. Chem. 21 (23): 4893-4908DOI: 10.1039/D3OB00385J
2022
Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production
Stevanovic M, D'Agostino P, Mojicevic M, Gulder T, Nikodinovic-Runic J, Vojnovic S (2022)
J. Appl. Microbiol. 133 (4): 2560-2568DOI: 10.1111/jam.15726
Discovery and Heterologous Expression of Microginins from Microcystis aeruginosa LEGE 91341
Eusébio N, Castelo-Branco R, Sousa D, Preto M, D'Agostino P, Gulder T, Leão P (2022)
ACS Synth. Biol. 11 (10): 3493-3503DOI: 10.1021/acssynbio.2c00389
Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly
D'Agostino P, Seel C, Ji X, Gulder T, Gulder T (2022)
Nat. Chem. Biol. 18 (6): 652-658DOI: 10.1038/s41589-022-01013-7
2021
Final Destination? Pinpointing Hyella disjuncta sp. nov. PCC 6712 (Cyanobacteria) Based on Taxonomic Aspects, Multicellularity, Nitrogen Fixation and Biosynthetic Gene Clusters
Jung P, D’Agostino P, Brust K, Büdel B, Lakatos M (2021)
Life 11 (9)DOI: 10.3390/life11090916
Symphyonema bifilamentata sp. nov., the right Fischerella ambigua 108b: Half a decade of research on taxonomy and bioactive compounds in new light
Jung P, D’Agostino P, Büdel B, Lakatos M (2021)
Microorganisms 9 (4)DOI: 10.3390/microorganisms9040745
Antarctic desert soil bacteria exhibit high novel natural product potential, evaluated through long-read genome sequencing and comparative genomics
Benaud N, Edwards R, Amos T, D'Agostino P, Gutiérrez-Chávez C, Montgomery K, Nicetic I, Ferrari B (2021)
Environ. Microbiol. 23 (7): 3646-3664DOI: 10.1111/1462-2920.15300
2020
Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties
Mojicevic M, D'Agostino P, Pavic A, Vojnovic S, Senthamaraikannan R, Vasiljevic B, Gulder T, Nikodinovic-Runic J (2020)
MicrobiologyOpen 9 (3)DOI: 10.1002/mbo3.986
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity
Wylensek D, Hitch T, Riedel T, Afrizal A, Kumar N, Wortmann E, Liu T, Devendran S, Lesker T, Hernández S, …, Overmann J, Clavel T (2020)
Nat. Commun. 11 (1)DOI: 10.1038/s41467-020-19929-w
Discovery of the Streptoketides by Direct Cloning and Rapid Heterologous Expression of a Cryptic PKS II Gene Cluster from Streptomyces sp. Tü 6314
Qian Z, Bruhn T, D'Agostino P, Herrmann A, Haslbeck M, Antal N, Fiedler H, Brack-Werner R, Gulder T (2020)
J. Org. Chem. 85 (2): 664-673DOI: 10.1021/acs.joc.9b02741
2019
Antifungal potential of bacterial rhizosphere isolates associated with three ethno-medicinal plants (poppy, chamomile, and nettle)
Mojicevic M, D'Agostino P, Nikodinovic-Runic J, Vasiljevic B, Gulder T, Vojnovic S (2019)
Int. Microbiol. 22 (3): 343-353DOI: 10.1007/s10123-019-00054-8
Bypassing Biocatalytic Substrate Limitations in Oxidative Dearomatization Reactions by Transient Substrate Mimicking
Milzarek T, Einsiedler M, Aldemir H, D'Agostino P, Evers J, Hertrampf G, Lamm K, Malay M, Matura A, Müller J, Gulder T (2019)
Org. Lett. 21 (12): 4520-4524DOI: 10.1021/acs.orglett.9b01398
Direct pathway cloning of the sodorifen biosynthetic gene cluster and recombinant generation of its product in E. coli
Duell E, D'Agostino P, Shapiro N, Woyke T, Fuchs T, Gulder T (2019)
Microb. Cell Fact. 18 (1)DOI: 10.1186/s12934-019-1080-6
2018
Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression
D'Agostino P, Gulder T (2018)
ACS Synth. Biol. 7 (7): 1702-1708DOI: 10.1021/acssynbio.8b00151
Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential
Greunke C, Duell E, D'Agostino P, Glöckle A, Lamm K, Gulder T (2018)
Metab. Eng. 47: 334-345DOI: 10.1016/j.ymben.2018.03.010