Dr Tobias Milzarek
About
Tobias Milzarek studied chemistry at the Technical University of Munich and received his Master of Science in 2018 with a focus on organic chemistry and pharmaceutical radiochemistry. With a scholarship from the German Economy Foundation he started his PhD in the group of Prof. Tobias Gulder (Technical Biochemistry) at the Technical University of Dresden. After his PhD and a short postdoc at the TU Dresden, he moved his research career to Switzerland in 2022 for another postdoc in the Laboratory of Catalysis and Organic Synthesis (Prof. Jérôme Waser) at the École Polytechnique Fédérale de Lausanne. Since February 2024, Tobias has been working as a scientist in the Natural Products Biotechnology Department at HIPS.
His research focuses on the combination of biocatalysis and modern organic chemical synthesis methods resulting in the chemo-enzymatic total synthesis of anti-infective natural products. Together with Prof. Tobias A. M. Gulder, Tobias has already developed several substance libraries of bacterial and fungal natural product classes.
2025
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis
Milzarek T, Gulder T (2025)
Nat. Prod. Rep. 42: 482-500DOI: 10.1039/D4NP00059E
The Maculalactone Biosynthetic Gene Cluster, a Cryptic Furanolide Pathway Revealed in Nodularia sp. NIES-3585
D’Agostino P, Castro R, Uka V, Saurav K, Milzarek T, Sester A, Schneider M, Gulder T (2025)
bioRxivDOI: 10.1101/2025.02.26.640319
2023
Antibiotic Potential of the Ambigol Cyanobacterial Natural Product Class and Simplified Synthetic Analogs
Milzarek T, Stevanovic M, Milivojevic D, Vojnovic S, Iliasov D, Wolf D, Mascher T, Nikodinovic-Runic J, Gulder T (2023)
ACS Infect. Dis. 9 (10): 1941-1948DOI: 10.1021/acsinfecdis.3c00232
Chemo-enzymatic total synthesis of the spirosorbicillinols
Milzarek T, Gulder T (2023)
Commun. Chem. 6 (1)DOI: 10.1038/s42004-023-00996-1
One-pot synthesis of functionalized bis(trifluoromethylated)benziodoxoles from iodine(I) precursors
Milzarek T, Ramirez N, Liu X, Waser J (2023)
Chem. Commun. 59 (84): 12637-12640DOI: 10.1039/D3CC04525K
Synthesis of Trifluoromethylated Alkenes: Hypervalent Iodine Meets High-Valent Copper
Milzarek T, Waser J (2023)
Angew. Chem. Int. Ed. 62 (33)DOI: 10.1002/anie.202306128
2022
Carrier Protein-Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC
Aldemir H, Shu S, Schaefers F, Hong H, Richarz R, Harteis S, Einsiedler M, Milzarek T, Schneider S, Gulder T (2022)
Chem. Eur. J. 28 (2)DOI: 10.1002/chem.202103389
Evaluation of the Substrate Promiscuity of SorbC for the Chemo-Enzymatic Total Synthesis of Structurally Diverse Sorbicillinoids
Milzarek T, Schuler S, Matura A, Gulder T (2022)
ACS Catal. 12 (3): 1898-1904DOI: 10.1021/acscatal.1c05196
Front Cover: Carrier Protein‐Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC (Chem. Eur. J. 2/2022)
Aldemir H, Shu S, Schaefers F, Hong H, Richarz R, Harteis S, Einsiedler M, Milzarek T, Schneider S, Gulder T (2022)
Chem. Eur. J. 28 (2)DOI: 10.1002/chem.202104450
2021
Total Synthesis of the Ambigols: A Cyanobacterial Class of Polyhalogenated Natural Products
Milzarek T, Gulder T (2021)
Org. Lett. 23 (1): 102-106DOI: 10.1021/acs.orglett.0c03784
2020
Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential
Sib A, Milzarek T, Herrmann A, Oubraham L, Müller J, Pichlmair A, Brack-Werner R, Gulder T (2020)
ChemBioChem 21 (4): 492-495DOI: 10.1002/cbic.201900472
Identification, cloning, expression and functional interrogation of the biosynthetic pathway of the polychlorinated triphenyls ambigol A–C from Fischerella ambigua 108b
Duell E, Milzarek T, El Omari M, Linares-Otoya L, Schäberle T, König G, Gulder T (2020)
Org. Chem. Front. 7 (20): 3193-3201DOI: 10.1039/D0QO00707B
Discovery and Comparison of Homogeneous Catalysts in a Standardized HOT‐CAT Screen with Microwave‐Heating and qNMR Analysis: Exploring Catalytic Hydration of Alkynes
Schreyer M, Milzarek T, Wegmann M, Brunner A, Hintermann L (2020)
ChemCatChem 12 (1): 152-168DOI: 10.1002/cctc.201900456
2019
Bypassing Biocatalytic Substrate Limitations in Oxidative Dearomatization Reactions by Transient Substrate Mimicking
Milzarek T, Einsiedler M, Aldemir H, D'Agostino P, Evers J, Hertrampf G, Lamm K, Malay M, Matura A, Müller J, Gulder T (2019)
Org. Lett. 21 (12): 4520-4524DOI: 10.1021/acs.orglett.9b01398