Andreas Keller studied bioinformatics at Saarland University in Saarbrücken from 2002 to 2005, and completed his doctoral studies in bioinformatics by 2009. Following this, he transitioned to industry and worked, among others, for Siemens Healthineers until 2013. In Erlangen, he led the Diagnostic Innovations group while also completing his habilitation in human genetics at Saarland University Hospital. Since 2013, Keller has been a Full Professor of Clinical Bioinformatics at Saarland University, and has been associated with HIPS since 2018. From 2019 to 2021, he served as a Visiting Professor at Stanford University in California. Since 2022, in addition to his university professorship, he has also been heading the department of Clinical Bioinformatics at HIPS.

Keller's research focuses on using computer-assisted methods to analyze RNAs. One area of research is on the regulatory mechanisms of non-coding RNAs, as well as the effect of various influencing factors on the single-cell transcriptome, which is resolved in both time and space. Based on his experience in modeling regulatory influences, Keller has dedicated his HIPS department to studying the interaction of bacteria with humans. In this research, he explores the exchange of information and material between commensal and pathogenic bacteria, as well as their host. The goal is to find new producers of natural products and identify new natural products, which can serve as a starting point for the development of new active substances. From a medical point of view, his research aims to better understand and influence the aging process, as well as neurodegenerative diseases such as Alzheimer's and Parkinson's.