Prof Dr Tobias Gulder
About
Tobias A. M. Gulder holds degrees in Chemistry from the University of Würzburg (Diploma 2004, PhD 2008). After postdoctoral training at the Scripps Institution of Oceanography with Bradley Moore (2008-2010) he started his independent work as a Liebig and Emmy Noether fellow at the University of Bonn (2011-2014) mentored by Jörn Piel. In 2014 he accepted the offer to join the Technical University of Munich as Professor of Biosystems Chemistry at the Department of Chemistry and the Center for Integrated Protein Science Munich (CIPSM). In 2019 he became the Chair of Technical Biochemistry at the Technical University of Dresden. Since 2024 he is chair of Natural Product Biotechnology at the Universität des Saarlands and Department Head at the Helmholtz Institute for Pharmaceutical Sciences. His group is interested in the structure, biosynthesis and synthesis of bacterial natural products. This includes the elucidation of new biosynthetic transformations and their application to the biocatalytic synthesis of natural products as well as the manipulation of biosynthetic pathways to generate new molecular structures. Since 2017 he is member and since 2019 Chair of the Editorial Board of the Journal Natural Product Reports (RSC).
Tobias A. M. Gulder received, i.a., the following awards:
- 2023 Henriette Herz Scout (Alexander von Humboldt Foundation)
- 2022, 2023 Teaching Awards of the Chemistry and Food Chemistry at TU Dresden
- 2019 ChemBioTalent selected by ChemBioChem
- 2017 Arnold Sommerfeld Award of the Bavarian Academy of Sciences
- 2016 Ernst Otto Fischer Teaching Award
- 2016 DECHEMA Natural Product Chemistry Early Career Award
- 2016 Max-Buchner Research Scholarship
- 2015 BASF Creator Space Science Symposium Award
- 2013 Thieme Chemistry Journal Award
- 2012 Member of the Junges Kolleg of the Nordrhein-Westfälischen Akademie der Wissenschaften und der Künste
- 2011 Emmy Noether Fellowship of the DFG
- 2011 Liebig Stipendium of the FCI
- 2009 DECHEMA Natural Product Chemistry PhD Award
- 2008 DAAD Postdoctoral Scholarship
- 2008 Award of the Faculty of Chemistry and Pharmacy 2007/2008, University of Würzburg, Germany, for an outstanding PhD thesis
2025
Heterologous Expression and Optimization of Fermentation Conditions for Recombinant Ikarugamycin Production
Evers J, Glöckle A, Wiegand M, Schuler S, Einsiedler M, Gulder T (2025)
Biotechnol. Bioeng.DOI: 10.1002/bit.28919
Homophenylalanine-derived benzo1,4diazepine-2,5-diones are strong bacterial quorum sensing inhibitors
Einsiedler M, Bogojevic S, Milivojevic D, Vojnovic S, Milcic M, Maslak V, Matura A, Gulder T, Nikodinovic-Runic J (2025)
Org. Biomol. Chem. 23 (4): 835-843DOI: 10.1039/d4ob01734j
Heterologous Expression of a Cryptic BGC from Bilophila sp. Provides Access to a Novel Family of Antibacterial Thiazoles
Hohmann M, Iliasov D, Larralde M, Johannes W, Janßen K, Zeller G, Mascher T, Gulder T (2025)
ACS. Synth. Biol.DOI: 10.1021/acssynbio.5c00042
A plug-and-play system for polycyclic tetramate macrolactam production and functionalization
Glöckle A, Schuler S, Einsiedler M, Gulder T (2025)
Microb. Cell Fact. 24 (1)DOI: 10.1186/s12934-024-02630-8
The Maculalactone Biosynthetic Gene Cluster, a Cryptic Furanolide Pathway Revealed in Nodularia sp. NIES-3585
D’Agostino P, Castro R, Uka V, Saurav K, Milzarek T, Sester A, Schneider M, Gulder T (2025)
bioRxivDOI: 10.1101/2025.02.26.640319
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis
Milzarek T, Gulder T (2025)
Nat. Prod. Rep.DOI: 10.1039/d4np00059e
2024
Chemoenzymatic total synthesis of sorbicillactone A
Müller J, Gulder T (2024)
Commun. Chem. 7 (1)DOI: 10.1038/s42004-024-01126-1
Biosynthesis of brevinic acid from lawsone
Hohmann M, Ohlrogge J, Gulder T (2024)
Org. Biomol. Chem. 22 (34): 7035-7038DOI: 10.1039/D4OB01184H
Product Selectivity in Baeyer-Villiger Monooxygenase-Catalyzed Bacterial Alkaloid Core Structure Maturation
Einsiedler M, Lamm K, Ohlrogge J, Schuler S, Richter I, Lübken T, Gulder T (2024)
J. Am. Chem. Soc. 146 (23): 16203-16212DOI: 10.1021/jacs.4c04115
Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs
Behnsen A, Hertrampf G, Vojnovic S, Nikodinovic-Runic J, Gulder T (2024)
RSC Adv. 14 (47): 35215-35219DOI: 10.1039/D4RA05941G
Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics
Schmartz G, Rehner J, Gund M, Keller V, Molano L, Rupf S, Hannig M, Berger T, Flockerzi E, Seitz B, …, Bals R, Keller A (2024)
Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-52598-7
Expanding Polycyclic Tetramate Macrolactam (PoTeM) Core Structure Diversity by Chemo-Enzymatic Synthesis and Bioengineering
Schuler S, Einsiedler M, Evers J, Malay M, Uka V, Schneider S, Gulder T (2024)
Angew. Chem. Int. Ed.DOI: 10.1002/anie.202420335
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas
Mo X, Pu Q, Lübken T, Yu G, Malay M, D'Agostino P, Gulder T (2024)
Cell Chem. Biol. 31 (12): 2128-2137DOI: 10.1016/j.chembiol.2024.09.002
Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications
Ilic-Tomic T, Kramar A, Kostic M, Vojnovic S, Milovanovic J, Petkovic M, D'Agostino P, Gulder T, Nikodinovic-Runic J (2024)
Front. Bioeng. Biotechnol. 12DOI: 10.3389/fbioe.2024.1466757
Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro
Hohmann M, Brunner V, Johannes W, Schum D, Carroll L, Liu T, Sasaki D, Bosch J, Clavel T, Sieber S, …, Janßen K, Gulder T (2024)
Commun. Biol. 7 (1)DOI: 10.1038/s42003-024-06208-3
2023
Antibiotic Potential of the Ambigol Cyanobacterial Natural Product Class and Simplified Synthetic Analogs
Milzarek T, Stevanovic M, Milivojevic D, Vojnovic S, Iliasov D, Wolf D, Mascher T, Nikodinovic-Runic J, Gulder T (2023)
ACS Infect. Dis. 9 (10): 1941-1948DOI: 10.1021/acsinfecdis.3c00232
Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster
Ouyang X, D'Agostino P, Wahlsten M, Delbaje E, Jokela J, Permi P, Gaiani G, Poso A, Bartos P, Gulder T, Koistinen H, Fewer D (2023)
Org. Biomol. Chem. 21 (23): 4893-4908DOI: 10.1039/D3OB00385J
Chemo-enzymatic total synthesis of the spirosorbicillinols
Milzarek T, Gulder T (2023)
Commun. Chem. 6 (1)DOI: 10.1038/s42004-023-00996-1
Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A
Hertrampf G, Vojnovic S, Müller J, Merten C, Nikodinovic-Runic J, Gulder T (2023)
J. Org. Chem. 88 (19): 14184-14188DOI: 10.1021/acs.joc.3c01285
Discovery of extended product structural space of the fungal dioxygenase AsqJ
Einsiedler M, Gulder T (2023)
Nat. Commun. 14 (1)DOI: 10.1038/s41467-023-39111-2
2022
Carrier Protein-Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC
Aldemir H, Shu S, Schaefers F, Hong H, Richarz R, Harteis S, Einsiedler M, Milzarek T, Schneider S, Gulder T (2022)
Chem. Eur. J. 28 (2)DOI: 10.1002/chem.202103389
Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production
Stevanovic M, D'Agostino P, Mojicevic M, Gulder T, Nikodinovic-Runic J, Vojnovic S (2022)
J. Appl. Microbiol. 133 (4): 2560-2568DOI: 10.1111/jam.15726
Discovery and Heterologous Expression of Microginins from Microcystis aeruginosa LEGE 91341
Eusébio N, Castelo-Branco R, Sousa D, Preto M, D'Agostino P, Gulder T, Leão P (2022)
ACS. Synth. Biol. 11 (10): 3493-3503DOI: 10.1021/acssynbio.2c00389
Evaluation of the Substrate Promiscuity of SorbC for the Chemo-Enzymatic Total Synthesis of Structurally Diverse Sorbicillinoids
Milzarek T, Schuler S, Matura A, Gulder T (2022)
ACS Catal. 12 (3): 1898-1904DOI: 10.1021/acscatal.1c05196
Front Cover: Carrier Protein‐Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC (Chem. Eur. J. 2/2022)
Aldemir H, Shu S, Schaefers F, Hong H, Richarz R, Harteis S, Einsiedler M, Milzarek T, Schneider S, Gulder T (2022)
Chem. Eur. J. 28 (2)DOI: 10.1002/chem.202104450
Strong Antibiotic Activity of the Myxocoumarin Scaffold in vitro and in vivo
Hertrampf G, Kusserow K, Vojnovic S, Pavic A, Müller J, Nikodinovic-Runic J, Gulder T (2022)
Chem. Eur. J. 28 (32)DOI: 10.1002/chem.202200394
Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly
D'Agostino P, Seel C, Ji X, Gulder T, Gulder T (2022)
Nat. Chem. Biol. 18 (6): 652-658DOI: 10.1038/s41589-022-01013-7
Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead
Bauman K, Shende V, Chen P, Trivella D, Gulder T, Vellalath S, Romo D, Moore B (2022)
Nat. Chem. Biol. 18 (5): 538-546DOI: 10.1038/s41589-022-00993-w
2021
Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones
Einsiedler M, Jamieson C, Maskeri M, Houk K, Gulder T (2021)
Angew. Chem. Int. Ed. 60 (15): 8297-8302DOI: 10.1002/anie.202017086
Total Synthesis of the Ambigols: A Cyanobacterial Class of Polyhalogenated Natural Products
Milzarek T, Gulder T (2021)
Org. Lett. 23 (1): 102-106DOI: 10.1021/acs.orglett.0c03784
Biosynthetic strategies for tetramic acid formation
Mo X, Gulder T (2021)
Nat. Prod. Rep. 38 (9): 1555-1566DOI: 10.1039/D0NP00099J
2020
Enzymes in natural product total synthesis
Moore B, Gulder T (2020)
Nat. Prod. Rep. 37 (10): 1292-1293DOI: 10.1039/D0NP90038A
Discovery of the Streptoketides by Direct Cloning and Rapid Heterologous Expression of a Cryptic PKS II Gene Cluster from Streptomyces sp. Tü 6314
Qian Z, Bruhn T, D'Agostino P, Herrmann A, Haslbeck M, Antal N, Fiedler H, Brack-Werner R, Gulder T (2020)
J. Org. Chem. 85 (2): 664-673DOI: 10.1021/acs.joc.9b02741
Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential
Sib A, Milzarek T, Herrmann A, Oubraham L, Müller J, Pichlmair A, Brack-Werner R, Gulder T (2020)
ChemBioChem 21 (4): 492-495DOI: 10.1002/cbic.201900472
Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties
Mojicevic M, D'Agostino P, Pavic A, Vojnovic S, Senthamaraikannan R, Vasiljevic B, Gulder T, Nikodinovic-Runic J (2020)
MicrobiologyOpen 9 (3)DOI: 10.1002/mbo3.986
Identification, cloning, expression and functional interrogation of the biosynthetic pathway of the polychlorinated triphenyls ambigol A–C from Fischerella ambigua 108b
Duell E, Milzarek T, El Omari M, Linares-Otoya L, Schäberle T, König G, Gulder T (2020)
Org. Chem. Front. 7 (20): 3193-3201DOI: 10.1039/D0QO00707B
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity
Wylensek D, Hitch T, Riedel T, Afrizal A, Kumar N, Wortmann E, Liu T, Devendran S, Lesker T, Hernández S, …, Overmann J, Clavel T (2020)
Nat. Commun. 11 (1)DOI: 10.1038/s41467-020-19929-w
Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Nephthea Sp. Supported by Metabolomics Analysis and Docking Studies
Abdelhafez O, Ali T, Fahim J, Desoukey S, Ahmed S, Behery F, Kamel M, Gulder T, Abdelmohsen U (2020)
Int. J. Nanomedicine 15: 5345-5360DOI: 10.2147/IJN.S239513
2019
Antifungal potential of bacterial rhizosphere isolates associated with three ethno-medicinal plants (poppy, chamomile, and nettle)
Mojicevic M, D'Agostino P, Nikodinovic-Runic J, Vasiljevic B, Gulder T, Vojnovic S (2019)
Int. Microbiol. 22 (3): 343-353DOI: 10.1007/s10123-019-00054-8
Synthesis and initial biological evaluation of myxocoumarin B
Müller J, Kusserow K, Hertrampf G, Pavic A, Nikodinovic-Runic J, Gulder T (2019)
Org. Biomol. Chem. 17 (7): 1966-1969DOI: 10.1039/C8OB02273A
Bypassing Biocatalytic Substrate Limitations in Oxidative Dearomatization Reactions by Transient Substrate Mimicking
Milzarek T, Einsiedler M, Aldemir H, D'Agostino P, Evers J, Hertrampf G, Lamm K, Malay M, Matura A, Müller J, Gulder T (2019)
Org. Lett. 21 (12): 4520-4524DOI: 10.1021/acs.orglett.9b01398
Structures and biological activities of cycloheptamycins A and B
Qian Z, Antosch J, Wiese J, Imhoff J, Fiedler H, Pöthig A, Gulder T (2019)
Org. Biomol. Chem. 17 (27): 6595-6600DOI: 10.1039/c9ob01261c
Direct pathway cloning of the sodorifen biosynthetic gene cluster and recombinant generation of its product in E. coli
Duell E, D'Agostino P, Shapiro N, Woyke T, Fuchs T, Gulder T (2019)
Microb. Cell Fact. 18 (1)DOI: 10.1186/s12934-019-1080-6
2018
New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes
El-Hawary S, Sayed A, Mohammed R, Khanfar M, Rateb M, Mohammed T, Hajjar D, Hassan H, Gulder T, Abdelmohsen U (2018)
Front. Chem. 6DOI: 10.3389/fchem.2018.00538
Chemo-enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone, and (+)-Epoxysorbicillinol
Sib A, Gulder T (2018)
Angew. Chem. Int. Ed. 57 (44): 14650-14653DOI: 10.1002/anie.201802176
Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression
D'Agostino P, Gulder T (2018)
ACS. Synth. Biol. 7 (7): 1702-1708DOI: 10.1021/acssynbio.8b00151
New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67
Ibrahim A, Attia E, Hajjar D, Anany M, Desoukey S, Fouad M, Kamel M, Wajant H, Gulder T, Abdelmohsen U (2018)
Mar. Drugs 16 (9)DOI: 10.3390/md16090290
Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential
Greunke C, Duell E, D'Agostino P, Glöckle A, Lamm K, Gulder T (2018)
Metab. Eng. 47: 334-345DOI: 10.1016/j.ymben.2018.03.010
A Pericyclic Reaction Cascade in Leporin Biosynthesis
Glöckle A, Gulder T (2018)
Angew. Chem. Int. Ed. 57 (11): 2754-2756DOI: 10.1002/anie.201800629
Natural Product Potential of the Genus Nocardiopsis
Ibrahim A, Desoukey S, Fouad M, Kamel M, Gulder T, Abdelmohsen U (2018)
Mar. Drugs 16 (5)DOI: 10.3390/md16050147
2017
Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae, A Rich Source of Novel Natural Product (Bio-)Chemistry
Kusserow K, Gulder T (2017)
J. Genomics 5: 75-76DOI: 10.7150/jgen.19673
Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B
Wiese J, Aldemir H, Schmaljohann R, Gulder T, Imhoff J (2017)
Mar. Drugs 15 (6)DOI: 10.3390/md15060191
Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N-Methylation in Omphalotin Biosynthesis
Aldemir H, Gulder T (2017)
Angew. Chem. Int. Ed. 56 (44): 13570-13572DOI: 10.1002/anie.201708456
Biocatalytic Total Synthesis of Ikarugamycin
Greunke C, Glöckle A, Antosch J, Gulder T (2017)
Angew. Chem. Int. Ed. 56 (15): 4351-4355DOI: 10.1002/anie.201611063
Stereoselective Total Synthesis of Bisorbicillinoid Natural Products by Enzymatic Oxidative Dearomatization/Dimerization
Sib A, Gulder T (2017)
Angew. Chem. Int. Ed. 56 (42): 12888-12891DOI: 10.1002/anie.201705976
Bioactive Natural Products of Marine Sponges from the Genus Hyrtios
Shady N, El-Hossary E, Fouad M, Gulder T, Kamel M, Abdelmohsen U (2017)
Molecules 22 (5)DOI: 10.3390/molecules22050781
2016
Extending Polyketide Structural Diversity by Using Engineered Carboxylase/Reductase Enzymes
Kundert J, Gulder T (2016)
Angew. Chem. Int. Ed. 55 (3): 858-60DOI: 10.1002/anie.201510402
Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β
Wiese J, Imhoff J, Gulder T, Labes A, Schmaljohann R (2016)
Mar. Drugs 14 (11)DOI: 10.3390/md14110200
2015
Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams--conversion of ikarugamycin to butremycin
Greunke C, Antosch J, Gulder T (2015)
Chem. Commun. 51 (25): 5334-6DOI: 10.1039/c5cc00843c
2014
Hydrofunktionalisierung mit unüblicher Regioselektivität
Gulder T, Gulder T (2014)
Nachr. Chem. 62 (9): 869-872DOI: 10.1002/nadc.201490290
Biosynthese im Reagenzglas
Gulder T, Gulder T (2014)
Nachr. Chem. 62 (11): 1081-1084DOI: 10.1002/nadc.201490379
Ein Sesquiterpen gegen das Vergessen
Gulder T, Gulder T (2014)
Nachr. Chem. 62 (7-8): 765-768DOI: 10.1002/nadc.201490256
H als Abgangsgruppe
Gulder T, Gulder T (2014)
Nachr. Chem. 62 (5): 534-537DOI: 10.1002/nadc.201490162
Heterologous reconstitution of ikarugamycin biosynthesis in E. coli
Antosch J, Schaefers F, Gulder T (2014)
Angew. Chem. Int. Ed. 53 (11): 3011-4DOI: 10.1002/anie.201310641
Structure of a putative fluorinated natural product from Streptomyces sp. TC1
Aldemir H, Kohlhepp S, Gulder T, Gulder T (2014)
J. Nat. Prod. 77 (11): 2331-4DOI: 10.1021/np500643g
Chemistry in stereo: the 49th Bürgenstock Conference
Gulder T, Gulder T (2014)
Angew. Chem. Int. Ed. 53 (36): 9418-20DOI: 10.1002/anie.201406309
Enantioselektive Fluorcyclisierungen
Gulder T, Gulder T (2014)
Nachr. Chem. 62 (1): 39-42DOI: 10.1002/nadc.201490011
The biocatalytic repertoire of natural biaryl formation
Aldemir H, Richarz R, Gulder T (2014)
Angew. Chem. Int. Ed. 53 (32): 8286-93DOI: 10.1002/anie.201401075
2013
The myxocoumarins A and B from Stigmatella aurantiaca strain MYX-030
Gulder T, Neff S, Schüz T, Winkler T, Gees R, Böhlendorf B (2013)
Beilstein J. Org. Chem. 9: 2579-85DOI: 10.3762/bjoc.9.293
Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses
Kampa A, Gagunashvili A, Gulder T, Morinaka B, Daolio C, Godejohann M, Miao V, Piel J, Andrésson Ó (2013)
Proc. Natl. Acad. Sci. 110 (33): 3129-37DOI: 10.1073/pnas.1305867110
Genome analysis of Pseudoalteromonas flavipulchra JG1 reveals various survival advantages in marine environment
Yu M, Tang K, Liu J, Shi X, Gulder T, Zhang X (2013)
BMC Genomics (BMC Genomics) 14DOI: 10.1186/1471-2164-14-707
2012
Isolation, structure elucidation and total synthesis of lajollamide A from the marine fungus Asteromyces cruciatus
Gulder T, Hong H, Correa J, Egereva E, Wiese J, Imhoff J, Gross H (2012)
Mar. Drugs 10 (12): 2912-35DOI: 10.3390/md10122912
Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis
Yamanaka K, Ryan K, Gulder T, Hughes C, Moore B (2012)
J. Am. Chem. Soc. 134 (30): 12434-7DOI: 10.1021/ja305670f
2011
Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit
Wilson M, Nam S, Gulder T, Kauffman C, Jensen P, Fenical W, Moore B (2011)
J. Am. Chem. Soc. 133 (6): 1971-7DOI: 10.1021/ja109226s
Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation
Lechner A, Eustáquio A, Gulder T, Hafner M, Moore B (2011)
Chem. Biol. 18 (12): 1527-36DOI: 10.1016/j.chembiol.2011.10.014
New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities
Pimentel-Elardo S, Buback V, Gulder T, Bugni T, Reppart J, Bringmann G, Ireland C, Schirmeister T, Hentschel U (2011)
Mar. Drugs 9 (10): 1682-1697DOI: 10.3390/md9101682
Atroposelective total synthesis of axially chiral biaryl natural products
Bringmann G, Gulder T, Gulder T, Breuning M (2011)
Chem. Rev. 111 (2): 563-639DOI: 10.1021/cr100155e
The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules
Gulder T, Freeman M, Piel J (2011)
Top. Curr. Chem.DOI: 10.1007/128_2010_113
2010
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics
Gulder T, Moore B (2010)
Angew. Chem. Int. Ed. 49 (49): 9346-67DOI: 10.1002/anie.201000728
Alterations to the structure of Leishmania major induced by N-arylisoquinolines correlate with compound accumulation and disposition
Ponte-Sucre A, Gulder T, Gulder T, Vollmers G, Bringmann G, Moll H (2010)
J. Med. Microbiol. 59 (Pt 1): 69-75DOI: 10.1099/jmm.0.014241-0
Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450
Wilson M, Gulder T, Mahmud T, Moore B (2010)
J. Am. Chem. Soc. 132 (36): 12757-65DOI: 10.1021/ja105891a
Total (bio)synthesis: strategies of nature and of chemists
Roberts A, Ryan K, Moore B, Gulder T (2010)
Top. Curr. Chem. 297: 149-203DOI: 10.1007/128_2010_79
2009
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica
Nett M, Gulder T, Kale A, Hughes C, Moore B (2009)
J. Med. Chem. 52 (19): 6163-7DOI: 10.1021/jm901098m
Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinone chrysophanol
Bringmann G, Gulder T, Hamm A, Goodfellow M, Fiedler H (2009)
Chem. Commun. (44): 6810-2DOI: 10.1039/B910501H
Chasing the treasures of the sea - bacterial marine natural products
Gulder T, Moore B (2009)
Curr. Opin. Microbiol. 12 (3): 252-60DOI: 10.1016/j.mib.2009.05.002
Convergence in the biosynthesis of acetogenic natural products from plants, fungi, and bacteria
Bringmann G, Irmer A, Feineis D, Gulder T, Fiedler H (2009)
Phytochemistry 70 (15-16): 1776-86DOI: 10.1016/j.phytochem.2009.08.019
2008
The online assignment of the absolute configuration of natural products: HPLC-CD in combination with quantum chemical CD calculations
Bringmann G, Gulder T, Reichert M, Gulder T (2008)
Chirality 20 (5): 628-42DOI: 10.1002/chir.20557
Axially chiral beta,beta'-bisporphyrins: synthesis and configurational stability tuned by the central metals
Bringmann G, Götz D, Gulder T, Gehrke T, Bruhn T, Kupfer T, Radacki K, Braunschweig H, Heckmann A, Lambert C (2008)
J. Am. Chem. Soc. 130 (52): 17812-5DOI: 10.1021/ja8055886
Cebulactams A1 and A2, new macrolactams isolated from Saccharopolyspora cebuensis, the first obligate marine strain of the genus Saccharopolyspora
Pimentel-Elardo S, Gulder T, Hentschel U, Bringmann G (2008)
Tetrahedron Lett. 49 (48): 6889-6892DOI: 10.1016/j.tetlet.2008.09.094
Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671
Fiedler H, Dieter A, Gulder T, Kajahn I, Hamm A, Brown R, Jones A, Goodfellow M, Müller W, Bringmann G (2008)
J. Antibiot. 61 (7): 464-73DOI: 10.1038/ja.2008.63
2007
Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042
Bringmann G, Haagen Y, Gulder T, Gulder T, Heide L (2007)
J. Org. Chem. 72 (11): 4198-204DOI: 10.1021/jo0703404
Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A
Bringmann G, Gulder T, Lang G, Schmitt S, Stöhr R, Wiese J, Nagel K, Imhoff J (2007)
Mar. Drugs 5 (2): 23-30DOI: 10.3390/md502023
Synthesis, optical resolution, and configurational assignment of novel axially chiral quateraryls
Goel A, Singh F, Kumar V, Reichert M, Gulder T, Bringmann G (2007)
J. Org. Chem. 72 (20): 7765-8DOI: 10.1021/jo071097b
Differential accumulation of hyperforin and secohyperforin in Hypericum perforatum tissue cultures
Charchoglyan A, Abrahamyan A, Fujii I, Boubakir Z, Gulder T, Kutchan T, Vardapetyan H, Bringmann G, Ebizuka Y, Beerhues L (2007)
Phytochemistry 68 (21): 2670-7DOI: 10.1016/j.phytochem.2007.06.004
Parvistemins A–D, a new type of dimeric phenylethyl benzoquinones from Stemona parviflora Wright
Yang X, Gulder T, Reichert M, Tang C, Ke C, Ye Y, Bringmann G (2007)
Tetrahedron 63 (22): 4688-4694DOI: 10.1016/j.tet.2007.03.093
2006
Axially chiral directly beta,beta-linked bisporphyrins: synthesis and stereostructure
Bringmann G, Rüdenauer S, Götz D, Gulder T, Reichert M (2006)
Org. Lett. 8 (21): 4743-6DOI: 10.1021/ol061812o
Rubritalea marina gen. nov., sp. nov., a marine representative of the phylum 'Verrucomicrobia', isolated from a sponge (Porifera)
Scheuermayer M, Gulder T, Bringmann G, Hentschel U (2006)
Int. J. Syst. Evol. Microbiol. 56 (Pt 9): 2119-2124DOI: 10.1099/ijs.0.64360-0
Different polyketide folding modes converge to an identical molecular architecture
Bringmann G, Noll T, Gulder T, Grüne M, Dreyer M, Wilde C, Pankewitz F, Hilker M, Payne G, Jones A, Goodfellow M, Fiedler H (2006)
Nat. Chem. Biol. 2 (8): 429-33DOI: 10.1038/nchembio805
2005
Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14
Bringmann G, Lang G, Maksimenka K, Hamm A, Gulder T, Dieter A, Bull A, Stach J, Kocher N, Müller W, Fiedler H (2005)
Phytochemistry 66 (11): 1366-73DOI: 10.1016/j.phytochem.2005.04.010
The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Penicillium chrysogenum strain
Bringmann G, Lang G, Gulder T, Tsuruta H, Mühlbacher J, Maksimenka K, Steffens S, Schaumann K, Stöhr R, Wiese J, …, Boreiko O, Müller W (2005)
Tetrahedron 61 (30): 7252-7265DOI: 10.1016/j.tet.2005.05.026
A borderline case between meso and stable C1: an axially chiral, yet configurationally semi-stable biphenyl with two oppositely configured [10]paracyclophane portions
Bringmann G, Gulder T, Maksimenka K, Kuckling D, Tochtermann W (2005)
Tetrahedron 61 (30): 7241-7246DOI: 10.1016/j.tet.2005.05.027
Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis
Aiello A, D'Esposito M, Fattorusso E, Menna M, Müller W, Perovic-Ottstadt S, Tsuruta H, Gulder T, Bringmann G (2005)
Tetrahedron 61 (30): 7266-7270DOI: 10.1016/j.tet.2005.05.025